Angiogenesis involves the assembly of endothelial cells into capillaries from a pre-existing
vasculature. Because abnormal angiogenesis is a hallmark of many cancers, it is critical to
find factors that control this process. Endothelial cells are enriched in the anthrax receptor;
we therefore determined the effect of anthrax edema toxin (ET), an adenylyl cyclase, on
chemotaxis. cAMP generated by ET does not block proliferation or survival but causes
cytoskeletal changes and inhibits chemotaxis by primary human microvascular endothelial …