[HTML][HTML] Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells
H Song, J Suehiro, Y Kanki, Y Kawai, K Inoue… - Journal of Biological …, 2009 - ASBMB
Endothelial phenotypes are highly regulated in space and time by both transcriptional and
post-transcriptional mechanisms. There is increasing evidence that the GATA family of
transcription factors function as signal transducers, coupling changes in the extracellular
environment to changes in downstream target gene expression. Here we show that human
primary endothelial cells derived from large blood vessels express GATA2,-3, and-6. Of
these factors, GATA3 was expressed at the highest levels. In DNA microarrays of human …
post-transcriptional mechanisms. There is increasing evidence that the GATA family of
transcription factors function as signal transducers, coupling changes in the extracellular
environment to changes in downstream target gene expression. Here we show that human
primary endothelial cells derived from large blood vessels express GATA2,-3, and-6. Of
these factors, GATA3 was expressed at the highest levels. In DNA microarrays of human …