Characterization of the CDR3 structure of the Vβ21 T cell clone in patients with P210BCR-ABL-positive chronic myeloid leukemia and B-cell acute lymphoblastic …

X Zha, S Chen, L Yang, B Li, Y Chen, X Yan, Y Li - Human Immunology, 2011 - Elsevier
The clonally expanded T cells identified in most cancer patients that respond to tumor-
associated antigen such as P210BCR-ABL protein have definite, specific antitumor
cytotoxicity. T cell receptor (TCR) Vβ CDR3 repertoire diversity was analyzed in patients with
chronic myeloid leukemia (CML) and BCR-ABL+ B-cell acute lymphoblastic leukemia (B-
ALL) by GeneScan. A high frequency of oligoclonal expansion of the TCR Vβ21 subfamily
was observed in the peripheral blood of CML and B-ALL patients. These clonally expanded …