Targeting the glucocorticoid receptor in breast and prostate cancers
J Kach, SD Conzen, RZ Szmulewitz - Science translational medicine, 2015 - science.org
J Kach, SD Conzen, RZ Szmulewitz
Science translational medicine, 2015•science.orgSteroid receptors for androgens and estrogens have essential roles in prostate and breast
cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having
an important role in these cancers. Underscoring the cooperative nature of nuclear receptor
activity, data now suggest that GR function in prostate and breast cancers is dependent on
the tumor's concomitant androgen or estrogen receptor activity.
cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having
an important role in these cancers. Underscoring the cooperative nature of nuclear receptor
activity, data now suggest that GR function in prostate and breast cancers is dependent on
the tumor's concomitant androgen or estrogen receptor activity.
Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor’s concomitant androgen or estrogen receptor activity.
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