Cross-talk between nuclear receptors and nuclear factor κB

K De Bosscher, W Vanden Berghe, G Haegeman - Oncogene, 2006 - nature.com
Oncogene, 2006nature.com
A variety of studies have shown that some activated nuclear receptors (NRs), especially the
glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor,
can inhibit the activity of the transcription factor nuclear factor κB (NF-κB), which plays a key
role in the control of genes involved in inflammation, cell proliferation and apoptosis. This
review describes the molecular mechanisms of cross-talk between NRs and NF-κB and the
biological relevance of this cross-talk. The importance and mechanistic aspects of selective …
Abstract
A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor κB (NF-κB), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-κB and the biological relevance of this cross-talk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-κB-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes.
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