Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
CJ Gordon, EP Tchesnokov, E Woolner… - Journal of Biological …, 2020 - ASBMB
Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control
this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase
(RdRp), which is the likely target of the investigational nucleotide analogue remdesivir
(RDV). RDV shows broad-spectrum antiviral activity against RNA viruses, and previous
studies with RdRps from Ebola virus and Middle East respiratory syndrome coronavirus …
this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase
(RdRp), which is the likely target of the investigational nucleotide analogue remdesivir
(RDV). RDV shows broad-spectrum antiviral activity against RNA viruses, and previous
studies with RdRps from Ebola virus and Middle East respiratory syndrome coronavirus …
