Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues
JT Brozinick, ED Hawkins, AB Strawbridge… - Journal of Biological …, 2004 - ASBMB
Cell culture work suggests that signaling to polymerize cortical filamentous actin (F-actin)
represents a required pathway for the optimal redistribution of the insulin-responsive
glucose transporter, GLUT4, to the plasma membrane. Recent in vitro study further suggests
that the actin-regulatory neural Wiskott-Aldrich syndrome protein (N-WASP) mediates the
effect of insulin on the actin filament network. Here we tested whether similar cytoskeletal
mechanics are essential for insulin-regulated glucose transport in isolated rat epitrochlearis …
represents a required pathway for the optimal redistribution of the insulin-responsive
glucose transporter, GLUT4, to the plasma membrane. Recent in vitro study further suggests
that the actin-regulatory neural Wiskott-Aldrich syndrome protein (N-WASP) mediates the
effect of insulin on the actin filament network. Here we tested whether similar cytoskeletal
mechanics are essential for insulin-regulated glucose transport in isolated rat epitrochlearis …
