[HTML][HTML] Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin
G Ramakrishnan, G Davaakhuu, L Kaplun… - Journal of Biological …, 2014 - ASBMB
AKT/PKB kinases transmit insulin and growth factor signals downstream of
phosphatidylinositol 3-kinase (PI3K). AKT activation involves phosphorylation at two
residues, Thr 308 and Ser 473, mediated by PDK1 and the mammalian target of rapamycin
complex 2 (mTORC2), respectively. Impaired AKT activation is a key factor in metabolic
disorders involving insulin resistance, whereas hyperactivation of AKT is linked to cancer
pathogenesis. Here, we identify the cytoplasmic NAD+-dependent deacetylase, Sirt2, as a …
phosphatidylinositol 3-kinase (PI3K). AKT activation involves phosphorylation at two
residues, Thr 308 and Ser 473, mediated by PDK1 and the mammalian target of rapamycin
complex 2 (mTORC2), respectively. Impaired AKT activation is a key factor in metabolic
disorders involving insulin resistance, whereas hyperactivation of AKT is linked to cancer
pathogenesis. Here, we identify the cytoplasmic NAD+-dependent deacetylase, Sirt2, as a …