[HTML][HTML] Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment
JP Belman, RR Bian, EN Habtemichael, DT Li… - Journal of Biological …, 2015 - ASBMB
Insulin causes the exocytic translocation of GLUT4 glucose transporters to stimulate glucose
uptake in fat and muscle. Previous results support a model in which TUG traps GLUT4 in
intracellular, insulin-responsive vesicles termed GLUT4 storage vesicles (GSVs). Insulin
triggers TUG cleavage to release the GSVs; GLUT4 then recycles through endosomes
during ongoing insulin exposure. The TUG C terminus binds a GSV anchoring site
comprising Golgin-160 and possibly other proteins. Here, we report that the TUG C terminus …
uptake in fat and muscle. Previous results support a model in which TUG traps GLUT4 in
intracellular, insulin-responsive vesicles termed GLUT4 storage vesicles (GSVs). Insulin
triggers TUG cleavage to release the GSVs; GLUT4 then recycles through endosomes
during ongoing insulin exposure. The TUG C terminus binds a GSV anchoring site
comprising Golgin-160 and possibly other proteins. Here, we report that the TUG C terminus …