Comparison of angiotensin-(1–7), losartan and their combination on atherosclerotic plaque formation in apolipoprotein E knockout mice
J Yang, Y Sun, M Dong, X Yang, X Meng, R Niu… - Atherosclerosis, 2015 - Elsevier
Aims Inhibition of the classical renin-angiotensin system (RAS) has been proved to reduce
atherosclerosis. Recently, angiotensin-(1–7)[Ang-(1–7)], a new component of RAS, has
been shown to attenuate atherosclerosis formation. However, direct comparison of Ang-(1–
7) and angiotensin II type 1 receptor blocker (ARB) on atherogenesis is sparse. Here, we
investigated whether large dose of Ang-(1–7) and losartan are equivalent or the
combination of both is superior in reducing atherosclerotic plaque formation. Methods and …
atherosclerosis. Recently, angiotensin-(1–7)[Ang-(1–7)], a new component of RAS, has
been shown to attenuate atherosclerosis formation. However, direct comparison of Ang-(1–
7) and angiotensin II type 1 receptor blocker (ARB) on atherogenesis is sparse. Here, we
investigated whether large dose of Ang-(1–7) and losartan are equivalent or the
combination of both is superior in reducing atherosclerotic plaque formation. Methods and …