SIRT3 regulation of mitochondrial oxidative stress
AS Bause, MC Haigis - Experimental gerontology, 2013 - Elsevier
Mitochondria play a central role in the production of reactive oxygen species as byproducts
of metabolism and energy production. In order to protect cellular structures from oxidative
stress-induced damage, cells have evolved elegant mechanisms for mitochondrial ROS
detoxification. The mitochondrial sirtuin, SIRT3, is emerging as a pivotal regulator of
oxidative stress by deacetylation of substrates involved in both ROS production and
detoxification. This review will summarize recent findings on the regulation of mitochondrial …
of metabolism and energy production. In order to protect cellular structures from oxidative
stress-induced damage, cells have evolved elegant mechanisms for mitochondrial ROS
detoxification. The mitochondrial sirtuin, SIRT3, is emerging as a pivotal regulator of
oxidative stress by deacetylation of substrates involved in both ROS production and
detoxification. This review will summarize recent findings on the regulation of mitochondrial …