Effect of 1 night of total sleep deprivation on cerebrospinal fluid β-amyloid 42 in healthy middle-aged men: a randomized clinical trial
S Ooms, S Overeem, K Besse, MO Rikkert… - JAMA …, 2014 - jamanetwork.com
Importance Increasing evidence suggests a relationship between poor sleep and the risk of
developing Alzheimer disease. A previous study found an effect of sleep on β-amyloid (Aβ),
which is a key protein in Alzheimer disease pathology. Objective To determine the effect of 1
night of total sleep deprivation on cerebrospinal fluid Aβ42 protein levels in healthy middle-
aged men. Design, Setting, and Participants The Alzheimer, Wakefulness, and Amyloid
Kinetics (AWAKE) study at the Radboud Alzheimer Center, a randomized clinical trial that …
developing Alzheimer disease. A previous study found an effect of sleep on β-amyloid (Aβ),
which is a key protein in Alzheimer disease pathology. Objective To determine the effect of 1
night of total sleep deprivation on cerebrospinal fluid Aβ42 protein levels in healthy middle-
aged men. Design, Setting, and Participants The Alzheimer, Wakefulness, and Amyloid
Kinetics (AWAKE) study at the Radboud Alzheimer Center, a randomized clinical trial that …