Association of excessive daytime sleepiness with longitudinal β-amyloid accumulation in elderly persons without dementia
DZ Carvalho, EK St Louis, DS Knopman… - JAMA …, 2018 - jamanetwork.com
Importance Aging is associated with excessive daytime sleepiness (EDS), which has been
linked to cognitive decline in the elderly. However, whether EDS is associated with the
pathologic processes of Alzheimer disease remains unclear. Objective To investigate
whether EDS at baseline is associated with a longitudinal increase in regional β-amyloid
(Aβ) accumulation in a cohort of elderly individuals without dementia. Design, Setting, and
Participants This prospective analysis included participants enrolled in the Mayo Clinic …
linked to cognitive decline in the elderly. However, whether EDS is associated with the
pathologic processes of Alzheimer disease remains unclear. Objective To investigate
whether EDS at baseline is associated with a longitudinal increase in regional β-amyloid
(Aβ) accumulation in a cohort of elderly individuals without dementia. Design, Setting, and
Participants This prospective analysis included participants enrolled in the Mayo Clinic …