Allergen-induced substance P synthesis in large-diameter sensory neurons innervating the lungs
B Chuaychoo, DD Hunter, AC Myers, M Kollarik… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: Tachykinins such as substance P are localized in unmyelinated slow-
conducting C fibers that can be activated by noxious stimuli and tissue inflammation.
Substance P is seldom expressed in fast-conducting large-diameter (A-fiber) vagal sensory
neurons. We have previously found that allergic inflammation causes a phenotypic change
in tachykinergic innervation of the trachea such that the production of substance P is
induced in large-diameter sensory neurons projecting mechanosensitive A fibers to the …
conducting C fibers that can be activated by noxious stimuli and tissue inflammation.
Substance P is seldom expressed in fast-conducting large-diameter (A-fiber) vagal sensory
neurons. We have previously found that allergic inflammation causes a phenotypic change
in tachykinergic innervation of the trachea such that the production of substance P is
induced in large-diameter sensory neurons projecting mechanosensitive A fibers to the …