Cellular and molecular mediators of immune responses are increasingly implicated in acute
and chronic pain pathophysiologies. Here we demonstrate that passive cutaneous IgE/Ag
anaphylaxis provokes increased thermal sensitivity in the hind paw tissue of mice. The
murine anti-DNP IgE antibodies SPE-7 and ɛ26 are known to induce differential cytokine
production in bone marrow cultured mast cells in vitro without antigen challenge. We found a
novel, antigen-dependent heterogeneity in the thermal pain responses elicited in the hind …