BAC to the future: the use of bac transgenic mice for neuroscience research
N Heintz - Nature Reviews Neuroscience, 2001 - nature.com
Nature Reviews Neuroscience, 2001•nature.com
The development of methods for engineering bacterial artificial chromosomes (BACs), and
for the efficient production of BAC transgenic mice, has allowed the design of in vivo
approaches to the analysis of gene expression and function in the brain, which could not be
accomplished using traditional methods. These strategies have shed light on the functions of
single genes in the nervous system, and will accelerate the use of functional genomic
approaches to neuroscience research.
for the efficient production of BAC transgenic mice, has allowed the design of in vivo
approaches to the analysis of gene expression and function in the brain, which could not be
accomplished using traditional methods. These strategies have shed light on the functions of
single genes in the nervous system, and will accelerate the use of functional genomic
approaches to neuroscience research.
Abstract
The development of methods for engineering bacterial artificial chromosomes (BACs), and for the efficient production of BAC transgenic mice, has allowed the design of in vivo approaches to the analysis of gene expression and function in the brain, which could not be accomplished using traditional methods. These strategies have shed light on the functions of single genes in the nervous system, and will accelerate the use of functional genomic approaches to neuroscience research.
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