Pathogenesis of coronavirus disease 2019-associated kidney injury
The prevailing evidence does not support substantive or persistent infection of kidneys in
COVID-19 and indirect means of tissue injury are favored, although a 'hit and run'model
cannot be excluded. COVAN frequently occurs in patients with mild respiratory systems,
suggesting that innate and adaptive immune responses to SARS-CoV-2 infection may
provide the second hit needed for the development of collapsing glomerulopathy in
susceptible individuals.
COVID-19 and indirect means of tissue injury are favored, although a 'hit and run'model
cannot be excluded. COVAN frequently occurs in patients with mild respiratory systems,
suggesting that innate and adaptive immune responses to SARS-CoV-2 infection may
provide the second hit needed for the development of collapsing glomerulopathy in
susceptible individuals.
Summary
The prevailing evidence does not support substantive or persistent infection of kidneys in COVID-19 and indirect means of tissue injury are favored, although a ‘hit and run’model cannot be excluded. COVAN frequently occurs in patients with mild respiratory systems, suggesting that innate and adaptive immune responses to SARS-CoV-2 infection may provide the second hit needed for the development of collapsing glomerulopathy in susceptible individuals.
Lippincott Williams & Wilkins