[HTML][HTML] Human kidney spheroids and monolayers provide insights into SARS-CoV-2 renal interactions

D Omer, O Pleniceanu, Y Gnatek… - Journal of the …, 2021 - journals.lww.com
Background Although coronavirus disease 2019 (COVID-19) causes significan t morbidity,
mainly from pulmonary involvement, extrapulmonary symptoms are also major componen ts
of the disease. Kidney disease, usually presenting as AKI, is particularly severe among
patients with COVID-19. It is unknown, however, whether such injury results from direct
kidney infection with COVID-19's causative virus, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), or from indirect mechanisms. Methods Using ex vivo cell …