[HTML][HTML] N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on α3β1 integrin-mediated cell migration
Y Zhao, T Nakagawa, S Itoh, K Inamori, T Isaji… - Journal of biological …, 2006 - ASBMB
N-Acetylglucosaminyltransferase V (GnT-V) catalyzes the addition of β1, 6-GlcNAc
branching of N-glycans, which contributes to metastasis. N-Acetylglucosaminyltransferase III
(GnT-III) catalyzes the formation of a bisecting GlcNAc structure in N-glycans, resulting in the
suppression of metastasis. It has long been hypothesized that the suppression of GnT-V
product formation by the action of GnT-III would also exist in vivo, which will consequently
lead to the inhibition of biological functions of GnT-V. To test this, we draw a comparison …
branching of N-glycans, which contributes to metastasis. N-Acetylglucosaminyltransferase III
(GnT-III) catalyzes the formation of a bisecting GlcNAc structure in N-glycans, resulting in the
suppression of metastasis. It has long been hypothesized that the suppression of GnT-V
product formation by the action of GnT-III would also exist in vivo, which will consequently
lead to the inhibition of biological functions of GnT-V. To test this, we draw a comparison …