[HTML][HTML] Treatment advances for glioblastoma

ET Wong, NH Yamaguchi - Expert Review of Neurotherapeutics, 2011 - Taylor & Francis
ET Wong, NH Yamaguchi
Expert Review of Neurotherapeutics, 2011Taylor & Francis
Glioblastoma is a deadly disease and modest improvement has been made in patient
survival in previous decades. At initial diagnosis, treatment consists of maximum safe
surgical resection, followed by temozolomide chemoirradiation and then adjuvant
temozolomide alone [1]. This treatment results in a median survival of 14.6 months, a 2-year
survival of 27.2% and a 5-year survival of 9.8%[1]. At the time of tumor progression, the best
available treatment option consists of single-agent bevacizumab, a humanized monoclonal …
Glioblastoma is a deadly disease and modest improvement has been made in patient survival in previous decades. At initial diagnosis, treatment consists of maximum safe surgical resection, followed by temozolomide chemoirradiation and then adjuvant temozolomide alone [1]. This treatment results in a median survival of 14.6 months, a 2-year survival of 27.2% and a 5-year survival of 9.8%[1]. At the time of tumor progression, the best available treatment option consists of single-agent bevacizumab, a humanized monoclonal antibody against VEGF, or in combination with irinotecan or other cytotoxic chemotherapies [2]. Although patients experience improved neurological function, this improvement is nevertheless transient and overall survival is not prolonged. Therefore, new treatment strategies are being sought.
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