Gliomas make up approximately 30% of all brain and central nervous system tumors and
80% of all malignant brain tumors. Despite the frequency of gliomas, the etiology of these
tumors remains largely unknown. Diffuse gliomas, including astrocytomas and
oligodendrogliomas, belong to a single pathologic class but have very different histologies
and molecular etiologies. Recent genomic studies have identified separate molecular
subtypes within the glioma classification that appear to correlate with biological etiology …