Interleukin-2 and STAT5 in regulatory T cell development and function
SA Mahmud, LS Manlove, MA Farrar - Jak-Stat, 2013 - Taylor & Francis
SA Mahmud, LS Manlove, MA Farrar
Jak-Stat, 2013•Taylor & FrancisInterleukin-2 and its downstream target STAT5 have effects on many aspects of immune
function. This has been perhaps best documented in regulatory T cells. In this review we
summarize the initial findings supporting a role for IL2 and STAT5 in regulatory T cell
development and outline more recent studies describing how this critical signaling pathway
entrains regulatory T cell differentiation and affects regulatory T cell function.
function. This has been perhaps best documented in regulatory T cells. In this review we
summarize the initial findings supporting a role for IL2 and STAT5 in regulatory T cell
development and outline more recent studies describing how this critical signaling pathway
entrains regulatory T cell differentiation and affects regulatory T cell function.
Interleukin-2 and its downstream target STAT5 have effects on many aspects of immune function. This has been perhaps best documented in regulatory T cells. In this review we summarize the initial findings supporting a role for IL2 and STAT5 in regulatory T cell development and outline more recent studies describing how this critical signaling pathway entrains regulatory T cell differentiation and affects regulatory T cell function.
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