Loss of histone H3 K79 methyltransferase Dot1l facilitates kidney fibrosis by upregulating endothelin 1 through histone deacetylase 2
Background The progression rate of CKD varies substantially among patients. The genetic
and epigenetic contributions that modify how individual patients respond to kidney injury are
largely unknown. Emerging evidence has suggested that histone H3 K79 methyltransferase
Dot1l has an antifibrotic effect by repressing Edn1, which encodes endothelin 1 in the
connecting tubule/collecting duct. Methods To determine if deletion of the Dot1l gene is a
genetic and epigenetic risk factor through regulating Edn1, we studied four groups of mice …
and epigenetic contributions that modify how individual patients respond to kidney injury are
largely unknown. Emerging evidence has suggested that histone H3 K79 methyltransferase
Dot1l has an antifibrotic effect by repressing Edn1, which encodes endothelin 1 in the
connecting tubule/collecting duct. Methods To determine if deletion of the Dot1l gene is a
genetic and epigenetic risk factor through regulating Edn1, we studied four groups of mice …