[HTML][HTML] Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis?
B Fernandez-Fernandez, A Ortiz, C Gomez-Guerrero… - BMC nephrology, 2012 - Springer
BMC nephrology, 2012•Springer
Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme
inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria.
However, recent trials have questioned the renal safety of this approach. Our understanding
on the molecular effects of dual blockade in humans is incomplete. Case presentation We
present a patient with corticoid resistant nephrotic syndrome who developed marked
juxtaglomerular apparatus hyperplasia and renin expression in the context of dual …
inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria.
However, recent trials have questioned the renal safety of this approach. Our understanding
on the molecular effects of dual blockade in humans is incomplete. Case presentation We
present a patient with corticoid resistant nephrotic syndrome who developed marked
juxtaglomerular apparatus hyperplasia and renin expression in the context of dual …
Background
Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach. Our understanding on the molecular effects of dual blockade in humans is incomplete.
Case presentation
We present a patient with corticoid resistant nephrotic syndrome who developed marked juxtaglomerular apparatus hyperplasia and renin expression in the context of dual angiotensin system blockade.
Conclusions
Although renin may have profibrotic effects mediated by (pro)renin receptor activation, this report raises questions on the potential consequences of local renin activation on chronic kidney disease in patients with dual angiotensin blockade.
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