[HTML][HTML] Suppression of RIP3-dependent necroptosis by human cytomegalovirus
S Omoto, H Guo, GR Talekar, L Roback… - Journal of biological …, 2015 - ASBMB
Necroptosis is an alternate programmed cell death pathway that is unleashed by caspase-8
compromise and mediated by receptor-interacting protein kinase 3 (RIP3). Murine
cytomegalovirus (CMV) and herpes simplex virus (HSV) encode caspase-8 inhibitors that
prevent apoptosis together with competitors of RIP homotypic interaction motif (RHIM)-
dependent signal transduction to interrupt the necroptosis. Here, we show that pro-necrotic
murine CMV M45 mutant virus drives virus-induced necroptosis during nonproductive …
compromise and mediated by receptor-interacting protein kinase 3 (RIP3). Murine
cytomegalovirus (CMV) and herpes simplex virus (HSV) encode caspase-8 inhibitors that
prevent apoptosis together with competitors of RIP homotypic interaction motif (RHIM)-
dependent signal transduction to interrupt the necroptosis. Here, we show that pro-necrotic
murine CMV M45 mutant virus drives virus-induced necroptosis during nonproductive …