[HTML][HTML] RIPK3-mediated necroptosis regulates cardiac allograft rejection
A Pavlosky, A Lau, Y Su, D Lian, X Huang, Z Yin… - American Journal of …, 2014 - Elsevier
Cell death results in tissue damage and ultimately donor graft rejection and can occur as an
active molecular process through apoptotic, necrotic and newly identified receptor
interacting protein 1 and 3 kinase (RIPK1/3)-mediated necroptotic pathways. Necroptosis
leads to the release of inflammatory molecules which can activate host immune cells. This
pathway has yet to be studied in heart transplantation. We have found that necroptosis was
induced in murine cardiac microvascular endothelial cell (MVEC) under anti-apoptotic …
active molecular process through apoptotic, necrotic and newly identified receptor
interacting protein 1 and 3 kinase (RIPK1/3)-mediated necroptotic pathways. Necroptosis
leads to the release of inflammatory molecules which can activate host immune cells. This
pathway has yet to be studied in heart transplantation. We have found that necroptosis was
induced in murine cardiac microvascular endothelial cell (MVEC) under anti-apoptotic …