Preclinical evaluation of the immunomodulatory lymphocyte trafficking drug FTY 720 for HIV prevention in the female genital mucosa of macaques

M Morris, RD Aubert, K Butler… - Journal of medical …, 2014 - Wiley Online Library
M Morris, RD Aubert, K Butler, T Henning, J Mitchell, L Jenkins, D Garber, J McNicholl…
Journal of medical primatology, 2014Wiley Online Library
FTY720 has been shown to reduce inflammatory cytokines and immune cells in the genital
mucosa of macaques. This pilot study examined the ability of FTY720 to inhibit HIV
acquisition. Systemic treatment with FTY720 failed to prevent or delay vaginal SHIV
transmission.
Abstract
FTY720 has been shown to reduce inflammatory cytokines and immune cells in the genital mucosa of macaques. This pilot study examined the ability of FTY720 to inhibit HIV acquisition. Systemic treatment with FTY720 failed to prevent or delay vaginal SHIV transmission.
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