[HTML][HTML] Plasminogen receptors and their role in the pathogenesis of inflammatory, autoimmune and malignant disease
A Godier, BJ Hunt - Journal of Thrombosis and Haemostasis, 2013 - Elsevier
Plasminogen is the proenzyme of plasmin, the key protease of the fibrinolytic system, but its
role is not limited to fibrinolysis regulation. Plasminogen binds not only to fibrin, but also to
different receptors on cell surfaces, including the heterotetrameric complex Annexin A2‐
S100A10, enolase‐1, histone H2B and the plasminogen receptor Plg‐R KT. These
receptors localize plasmin generation to the cell surface and provide a broad spectrum of
reactions including proteolytic activity, cell migration and recruitment as well as signaling …
role is not limited to fibrinolysis regulation. Plasminogen binds not only to fibrin, but also to
different receptors on cell surfaces, including the heterotetrameric complex Annexin A2‐
S100A10, enolase‐1, histone H2B and the plasminogen receptor Plg‐R KT. These
receptors localize plasmin generation to the cell surface and provide a broad spectrum of
reactions including proteolytic activity, cell migration and recruitment as well as signaling …