Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise
B Przybyla, C Gurley, JF Harvey, E Bearden… - Experimental …, 2006 - Elsevier
Macrophages are involved in skeletal muscle repair through pro-inflammatory and
alternative functions. We tested the hypothesis that aging alters the abundance and
properties of skeletal muscle macrophages that will influence their functional response to
acute resistance exercise. Total macrophages (CD68+), as well as pro-(CD11b+) and anti-
inflammatory (CD163+) subpopulations and associated cytokine mRNAs were quantified in
vastus lateralis biopsies from young (N= 17) and elderly (N= 17) males pre-and 72h post …
alternative functions. We tested the hypothesis that aging alters the abundance and
properties of skeletal muscle macrophages that will influence their functional response to
acute resistance exercise. Total macrophages (CD68+), as well as pro-(CD11b+) and anti-
inflammatory (CD163+) subpopulations and associated cytokine mRNAs were quantified in
vastus lateralis biopsies from young (N= 17) and elderly (N= 17) males pre-and 72h post …