Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation

KA Murach, CS Fry, TJ Kirby, JR Jackson… - …, 2018 - journals.physiology.org
KA Murach, CS Fry, TJ Kirby, JR Jackson, JD Lee, SH White, EE Dupont-Versteegden…
Physiology, 2018journals.physiology.org
Recent loss-of-function studies show that satellite cell depletion does not promote
sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although
overload-induced muscle fiber hypertrophy is normally associated with satellite cell-
mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of
satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence
also indicates that satellite cells play an important role in remodeling the extracellular matrix …
Recent loss-of-function studies show that satellite cell depletion does not promote sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although overload-induced muscle fiber hypertrophy is normally associated with satellite cell-mediated myonuclear accretion, hypertrophic adaptation proceeds in the absence of satellite cells in fully grown adult mice, but not in young growing mice. Emerging evidence also indicates that satellite cells play an important role in remodeling the extracellular matrix during hypertrophy.
American Physiological Society