Frailty, dialysis initiation, and mortality in end-stage renal disease

Y Bao, L Dalrymple, GM Chertow… - Archives of internal …, 2012 - jamanetwork.com
Background In light of the recent trend toward earlier dialysis initiation and its association
with mortality among patients with end-stage renal disease, we hypothesized that frailty is
associated with higher estimated glomerular filtration rate (eGFR) at dialysis start and may
confound the relation between earlier dialysis initiation and mortality. Methods We examined
frailty among participants of the Comprehensive Dialysis Study (CDS), a special study of the
US Renal Data System, which enrolled incident patients from September 1, 2005, through …