Ammonia is a cytotoxic molecule generated during normal cellular functions. Dysregulated
ammonia metabolism, which is evident in many chronic diseases such as liver cirrhosis,
heart failure, and chronic obstructive pulmonary disease, initiates a hyperammonemic stress
response in tissues including skeletal muscle and in myotubes. Perturbations in levels of
specific regulatory molecules have been reported, but the global responses to
hyperammonemia are unclear. In this study, we used a multiomics approach to vertically …