Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of l-leucine in cirrhosis
G Davuluri, D Krokowski, BJ Guan, A Kumar… - Journal of …, 2016 - Elsevier
Background & Aims Increased skeletal muscle ammonia uptake with loss of muscle mass
adversely affects clinical outcomes in cirrhosis. Hyperammonemia causes reduced protein
synthesis and sarcopenia but the cellular responses to impaired proteostasis and molecular
mechanism of l-leucine induced adaptation to ammonia induced stress were determined.
Methods Response to activation of amino acid deficiency sensor, GCN2, in the skeletal
muscle from cirrhotic patients and the portacaval anastomosis (PCA) rat were quantified …
adversely affects clinical outcomes in cirrhosis. Hyperammonemia causes reduced protein
synthesis and sarcopenia but the cellular responses to impaired proteostasis and molecular
mechanism of l-leucine induced adaptation to ammonia induced stress were determined.
Methods Response to activation of amino acid deficiency sensor, GCN2, in the skeletal
muscle from cirrhotic patients and the portacaval anastomosis (PCA) rat were quantified …