Serum globulin in myasthenia gravis: inhibition of α-bungarotoxin binding to acetylcholine receptors
RR Almon, CG Andrew, SH Appel - Science, 1974 - science.org
RR Almon, CG Andrew, SH Appel
Science, 1974•science.orgSerum factors that inhibit the binding of 125I-labeled α-bungarotoxin to the acetylcholine
receptor extracted in detergent from denervated rat muscle were detected by a sensitive
assay. The serum of at least 5 and possibly 11 out of 15 patients with myasthenia gravis
showed inhibitory activity that was localized to the globulin fraction. No controls showed
inhibitory activity. The demonstration of inhibitory globulins may help explain the
involvement of the immune system in the pathophysiology of the neuromuscular junction in …
receptor extracted in detergent from denervated rat muscle were detected by a sensitive
assay. The serum of at least 5 and possibly 11 out of 15 patients with myasthenia gravis
showed inhibitory activity that was localized to the globulin fraction. No controls showed
inhibitory activity. The demonstration of inhibitory globulins may help explain the
involvement of the immune system in the pathophysiology of the neuromuscular junction in …
Serum factors that inhibit the binding of 125I-labeled α-bungarotoxin to the acetylcholine receptor extracted in detergent from denervated rat muscle were detected by a sensitive assay. The serum of at least 5 and possibly 11 out of 15 patients with myasthenia gravis showed inhibitory activity that was localized to the globulin fraction. No controls showed inhibitory activity. The demonstration of inhibitory globulins may help explain the involvement of the immune system in the pathophysiology of the neuromuscular junction in patients with myasthenia gravis.
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