Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation
N Hirschhausen, D Block, I Bianconi, A Bragonzi… - International Journal of …, 2013 - Elsevier
Staphylococcus aureus often persists in the airways of cystic fibrosis (CF) patients. There is
only limited knowledge about bacterial persistence in and adaptation to this new ecological
environment. Therefore, we used S. aureus isolates from a unique strain collection, in which
all S. aureus isolates recovered from CF patients from two CF centers were stored from more
than 150 CF patients for more than a decade. S. aureus early and late isolates from 71 CF
patients with long-term staphylococcal colonization of the airways (≥ 5 years) were …
only limited knowledge about bacterial persistence in and adaptation to this new ecological
environment. Therefore, we used S. aureus isolates from a unique strain collection, in which
all S. aureus isolates recovered from CF patients from two CF centers were stored from more
than 150 CF patients for more than a decade. S. aureus early and late isolates from 71 CF
patients with long-term staphylococcal colonization of the airways (≥ 5 years) were …