R-citalopram counteracts the antidepressant-like effect of escitalopram in a rat chronic mild stress model

C Sanchez, P Gruca, M Papp - Behavioural pharmacology, 2003 - journals.lww.com
Abstract The selective serotonin (5-HT) reuptake inhibitor, citalopram, is a racemic mixture of
the stereoisomers, S-(+)-citalopram (escitalopram) and R-(−)-citalopram (R-citalopram). R-
citalopram has been shown to counteract the 5-HT enhancing properties of escitalopram in
acute studies in animals. In the present study we report, for the first time, on an interaction
between R-citalopram and escitalopram after repeated dosing in a rat chronic mild stress
(CMS) model of depression. The effect of escitalopram (2.0, 3.9 and 7.8 mg/kg per day), R …