T cell receptor signalling in the control of regulatory T cell differentiation and function
MO Li, AY Rudensky - Nature Reviews Immunology, 2016 - nature.com
Nature Reviews Immunology, 2016•nature.com
Regulatory T cells (TReg cells), a specialized T cell lineage, have a pivotal function in the
control of self tolerance and inflammatory responses. Recent studies have revealed a
discrete mode of T cell receptor (TCR) signalling that regulates TReg cell differentiation,
maintenance and function and that affects gene expression, metabolism, cell adhesion and
migration of these cells. Here, we discuss the emerging understanding of TCR-guided
differentiation of TReg cells in the context of their function in health and disease.
control of self tolerance and inflammatory responses. Recent studies have revealed a
discrete mode of T cell receptor (TCR) signalling that regulates TReg cell differentiation,
maintenance and function and that affects gene expression, metabolism, cell adhesion and
migration of these cells. Here, we discuss the emerging understanding of TCR-guided
differentiation of TReg cells in the context of their function in health and disease.
Abstract
Regulatory T cells (TReg cells), a specialized T cell lineage, have a pivotal function in the control of self tolerance and inflammatory responses. Recent studies have revealed a discrete mode of T cell receptor (TCR) signalling that regulates TReg cell differentiation, maintenance and function and that affects gene expression, metabolism, cell adhesion and migration of these cells. Here, we discuss the emerging understanding of TCR-guided differentiation of TReg cells in the context of their function in health and disease.
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