Immature myeloid cells and cancer-associated immune suppression
S Kusmartsev, DI Gabrilovich - Cancer immunology, immunotherapy, 2002 - Springer
Cancer immunology, immunotherapy, 2002•Springer
Impaired balance between mature and immature myeloid cells is one of the hallmarks of
cancer. In cancer patients as well as in mouse models there is increasing evidence that
progressive tumor growth is associated with an accumulation of immature myeloid cells,
monocytes/macrophages, and with a decreased number and function of dendritic cells (DC).
This review examines recent findings on the contribution of immature myeloid cells (ImC) to
cancer-induced immune suppression.
cancer. In cancer patients as well as in mouse models there is increasing evidence that
progressive tumor growth is associated with an accumulation of immature myeloid cells,
monocytes/macrophages, and with a decreased number and function of dendritic cells (DC).
This review examines recent findings on the contribution of immature myeloid cells (ImC) to
cancer-induced immune suppression.
Abstract
Impaired balance between mature and immature myeloid cells is one of the hallmarks of cancer. In cancer patients as well as in mouse models there is increasing evidence that progressive tumor growth is associated with an accumulation of immature myeloid cells, monocytes/macrophages, and with a decreased number and function of dendritic cells (DC). This review examines recent findings on the contribution of immature myeloid cells (ImC) to cancer-induced immune suppression.
Springer