Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment
K Pawlak, A Buraczewska-Buczko, D Pawlak… - The American journal of …, 2010 - Elsevier
Background Disturbances of the fibrinolytic system and kynurenine (KYN) pathway of
tryptophan (TRP) metabolism have been postulated as important factors in the pathogenesis
of cardiovascular disease (CVD). However, no data are yet available on the associations
between these 2 systems in relation to CVD prevalence in patients with chronic renal failure
(CRF). Methods We evaluated TRP and its metabolites, KYN, 3-hydroxykynurenine, and
quinolinic acid (QA), and their relations with the parameters of the fibrinolytic system, such …
tryptophan (TRP) metabolism have been postulated as important factors in the pathogenesis
of cardiovascular disease (CVD). However, no data are yet available on the associations
between these 2 systems in relation to CVD prevalence in patients with chronic renal failure
(CRF). Methods We evaluated TRP and its metabolites, KYN, 3-hydroxykynurenine, and
quinolinic acid (QA), and their relations with the parameters of the fibrinolytic system, such …