Severe burn injury is associated with systemic coagulopathy. The changes in coagulation
described in patients with severe burns resemble those found patients with sepsis or major
trauma. Coagulopathy in patients with severe burns is characterized by procoagulant
changes, and impaired fibrinolytic and natural anticoagulation systems. Both the timing of
onset and the severity of hemostatic derangements are related to the severity of the burn.
The exact pathophysiology and time course of coagulopathy are uncertain, but, at least in …