The musculoskeletal system is critical for movement and the protection of organs. In addition
to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated
process of repair referred to as the acute‐phase response (APR). Dysfunctional APRs
caused by severe injuries or underlying chronic diseases are implicated in pathologic
musculoskeletal repair, resulting in decreased mobility and chronic pain. The molecular
mechanisms behind these phenomena are not well understood, hindering the development …