ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection

L Zhou, Z Xu, GM Castiglione, US Soiberman… - The ocular …, 2020 - Elsevier
Purpose Conjunctival signs and symptoms are observed in a subset of patients with COVID-
19, and SARS-CoV-2 has been detected in tears, raising concerns regarding the eye both
as a portal of entry and carrier of the virus. The purpose of this study was to determine
whether ocular surface cells possess the key factors required for cellular susceptibility to
SARS-CoV-2 entry/infection. Methods We analyzed human post-mortem eyes as well as
surgical specimens for the expression of ACE2 (the receptor for SARS-CoV-2) and …