Genetic polymorphism in pvmdr1 and pvcrt-o genes in relation to in vitro drug susceptibility of Plasmodium vivax isolates from malaria-endemic countries
F Lu, CS Lim, DH Nam, K Kim, K Lin, TS Kim, HW Lee… - Acta tropica, 2011 - Elsevier
Treatment failure of chloroquine for Plasmodium vivax infection has increased in endemic
countries. However, the molecular mechanisms for resistance and in vitro susceptibility of P.
vivax to chloroquine remain elusive. We investigated the prevalence of mutations in the
pvmdr1 and pvcrt-o genes, and the copy number of the pvmdr1 gene in isolates from the
Republic of Korea (ROK), Thailand, the Union of Myanmar (Myanmar), and Papua New
Guinea (PNG). We also measured in vitro susceptibility of Korean isolates to antimalarial …
countries. However, the molecular mechanisms for resistance and in vitro susceptibility of P.
vivax to chloroquine remain elusive. We investigated the prevalence of mutations in the
pvmdr1 and pvcrt-o genes, and the copy number of the pvmdr1 gene in isolates from the
Republic of Korea (ROK), Thailand, the Union of Myanmar (Myanmar), and Papua New
Guinea (PNG). We also measured in vitro susceptibility of Korean isolates to antimalarial …