Localization of Nav1. 5 sodium channel protein in the mouse brain
L Wu, K Nishiyama, JG Hollyfield, Q Wang - Neuroreport, 2002 - journals.lww.com
Abstract Na v 1.5 or SCN5A is a member of the voltage-dependent family of sodium
channels. The distribution of Na v 1.5 protein was investigated in the mouse brain using
immunohistochemistry. Immunostaining with a Na v 1.5-specific antibody revealed that Na v
1.5 protein was localized in certain distinct regions of brain including the cerebral cortex,
thalamus, hypothalamus, basal ganglia, cerebellum and brain stem. Notably, we found that
Na v 1.5 protein co-localized with neurofilaments and clustered at a high density in the …
channels. The distribution of Na v 1.5 protein was investigated in the mouse brain using
immunohistochemistry. Immunostaining with a Na v 1.5-specific antibody revealed that Na v
1.5 protein was localized in certain distinct regions of brain including the cerebral cortex,
thalamus, hypothalamus, basal ganglia, cerebellum and brain stem. Notably, we found that
Na v 1.5 protein co-localized with neurofilaments and clustered at a high density in the …