Phylogeny of ion channels: clues to structure and function
PAV Anderson, RM Greenberg - … and Physiology Part B: Biochemistry and …, 2001 - Elsevier
Voltage-gated ion channels are responsible for the electrical activity in a variety of cell types
in modern-day animals. However, they represent the result of many millions of years of
evolution of a family of ion channel proteins that are also found in prokaryotes and diverse
eukaryotes, and probably exist in all life forms. This review traces the evolution of ion
channels, with particular emphasis on the factors and evolutionary pathways that may have
given rise to voltage-gated potassium (K+), calcium (Ca2+), and sodium (Na+) channels …
in modern-day animals. However, they represent the result of many millions of years of
evolution of a family of ion channel proteins that are also found in prokaryotes and diverse
eukaryotes, and probably exist in all life forms. This review traces the evolution of ion
channels, with particular emphasis on the factors and evolutionary pathways that may have
given rise to voltage-gated potassium (K+), calcium (Ca2+), and sodium (Na+) channels …