[HTML][HTML] FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation
S Abdullah, ML Lynn, MT McConnell, MM Klass… - Journal of Biological …, 2019 - ASBMB
Mutations in the cardiac thin filament (TF) have highly variable effects on the regulatory
function of the cardiac sarcomere. Understanding the molecular-level dysfunction elicited by
TF mutations is crucial to elucidate cardiac disease mechanisms. The hypertrophic
cardiomyopathy–causing cardiac troponin T (cTnT) mutation Δ160Glu (Δ160E) is located in
a putative" hinge" adjacent to an unstructured linker connecting domains TNT1 and TNT2.
Currently, no high-resolution structure exists for this region, limiting significantly our ability to …
function of the cardiac sarcomere. Understanding the molecular-level dysfunction elicited by
TF mutations is crucial to elucidate cardiac disease mechanisms. The hypertrophic
cardiomyopathy–causing cardiac troponin T (cTnT) mutation Δ160Glu (Δ160E) is located in
a putative" hinge" adjacent to an unstructured linker connecting domains TNT1 and TNT2.
Currently, no high-resolution structure exists for this region, limiting significantly our ability to …