Radiation and the microenvironment–tumorigenesis and therapy

MH Barcellos-Hoff, C Park, EG Wright - Nature Reviews Cancer, 2005 - nature.com
MH Barcellos-Hoff, C Park, EG Wright
Nature Reviews Cancer, 2005nature.com
Radiation rapidly and persistently alters the soluble and insoluble components of the tissue
microenvironment. This affects the cell phenotype, tissue composition and the physical
interactions and signalling between cells. These alterations in the microenvironment can
contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples
of these responses and their implications are discussed with a view to therapeutic
intervention.
Abstract
Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.
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