Inhibition of Bcl-2/xl with ABT-263 selectively kills senescent type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice

J Pan, D Li, Y Xu, J Zhang, Y Wang, M Chen… - International Journal of …, 2017 - Elsevier
Purpose Ionizing radiation (IR)–induced pulmonary fibrosis (PF) is an irreversible and
severe late effect of thoracic radiation therapy. The goal of this study was to determine
whether clearance of senescent cells with ABT-263, a senolytic drug that can selectively kill
senescent cells, can reverse PF. Methods and Materials C57BL/6J mice were exposed to a
single dose of 17 Gy on the right side of the thorax. Sixteen weeks after IR, they were treated
with 2 cycles of vehicle or ABT-263 (50 mg/kg per day for 5 days per cycle) by gavage. The …