[HTML][HTML] A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription
EC Svensson, GS Huggins, FB Dardik, CE Polk… - Journal of Biological …, 2000 - ASBMB
GATA4 is a transcriptional activator of cardiac-restricted promoters and is required for
normal cardiac morphogenesis. Friend of GATA-2 (FOG-2) is a multizinc finger protein that
associates with GATA4 and represses GATA4-dependent transcription. To better understand
the transcriptional repressor activity of FOG-2 we performed a functional analysis of the FOG-
2 protein. The results demonstrated that 1) zinc fingers 1 and 6 of FOG-2 are each capable
of interacting with evolutionarily conserved motifs within the N-terminal zinc finger of …
normal cardiac morphogenesis. Friend of GATA-2 (FOG-2) is a multizinc finger protein that
associates with GATA4 and represses GATA4-dependent transcription. To better understand
the transcriptional repressor activity of FOG-2 we performed a functional analysis of the FOG-
2 protein. The results demonstrated that 1) zinc fingers 1 and 6 of FOG-2 are each capable
of interacting with evolutionarily conserved motifs within the N-terminal zinc finger of …
