Protective role of estrogen-induced miRNA-29 expression in carbon tetrachloride-induced mouse liver injury
Y Zhang, L Wu, Y Wang, M Zhang, L Li, D Zhu… - Journal of Biological …, 2012 - jbc.org
Previous studies have indicated that female animals are more resistant to carbon
tetrachloride (CCl 4)-induced liver fibrosis than male animals, and that estradiol (E 2)
treatment can inhibit CCl 4-induced animal hepatic fibrosis. The underlying mechanism
governing these phenomena, however, has not been fully elucidated. Here we reported the
role of estrogen-induced miRNA-29 (miR-29) expression in CCl 4-induced mouse liver
injury. Hepatic miR-29 levels were differentially regulated in female and male mice during …
tetrachloride (CCl 4)-induced liver fibrosis than male animals, and that estradiol (E 2)
treatment can inhibit CCl 4-induced animal hepatic fibrosis. The underlying mechanism
governing these phenomena, however, has not been fully elucidated. Here we reported the
role of estrogen-induced miRNA-29 (miR-29) expression in CCl 4-induced mouse liver
injury. Hepatic miR-29 levels were differentially regulated in female and male mice during …
